The 39-year-old Movistar Workforce rider and Tour favourite bested compatriot Demi Vollering by 3 minutes and 48 seconds within the eight-stage bike race. Katarzyna “Kasia” Niewiadoma of Poland completed third.
Van Vleuten, ranked No. 1 on the planet, gained phases seven and eight.
Vollering, of Workforce SD Worx, secured the polka dot jersey for the Queen of the Mountains competitors, whereas Shirin Van Anrooij, of Trek-Segafredowas better of the younger riders, securing the white jersey for 2022.
Canyon-SRAM Racing was the highest crew total, beating out FDJ-Suez-Futuroscope and Trek-Segafredo.
The race lined 1,029 kilometers (639 miles) in jap France, ending atop La Tremendous Planche des Belles Filles.
This was the primary ladies’s Tour de France since 1989.